Syringomyelia Awareness: We Need Your Help for Research

Are you a breeder or pet owner and with a cavalier of age 6 or older that you think might be a good candidate for a scan? Rupert’s Fund is on the search for older dogs CLEAR of Syringomyelia. To date, these have been very hard to find. Researchers know more are out there, but finding them before this research window closes is extremely important!

If you think your dog might be good candidate, please contact researcher Penny Knowler for further information. Discussions and scan results are absolutely confidential: results are shared with the owner (unless the owner does not wish to know the result), the genome researchers, and Dr Sarah Blott for the Estimated Breeding Values (EBV) project (more detail below).

What dogs are considered?

The researchers are seeking male cavaliers of age 6 or more that are believed to be clear for SM. These would be dogs that either have never been MRId and show no signs of SM, or dogs that were scanned clear at a younger age, which continue to show no symptoms. Eligible dogs need to have a Kennel Club registration number (or from another national registry such as the IKC, AKC or CKCSC) so that a pedigree can be constructed. If the owner has a five generation pedigree already, this can be submitted to the researchers. Please see the note at the bottom of this post!

Priority is given to dogs that come from a background considered most useful to the overall genome project, as determined by the researchers. Siblings or closely related dogs are considered especially valuable. Dogs need to be able to get to one of a group of specific scanning centres in the UK.

Who chooses the dogs, & sees the scans paid for by Rupert’s Fund?

◦Clare Rusbridge and Penny Knowler select the most promising dogs for the project (based on a number of criteria) and then pay for the scan out of Rupert’s Fund, which they manage themselves.

◦The scans are then seen by the owner of the dog, and the researchers.

That’s it!

As donors will notice when they make a donation, all donations to Rupert’s Fund go directly to Penny Knowler in the first place (the SM DNA Research fund).

Scan results and discussions are entirely between the owner and the researchers in the UK and Canada. No report is made back to anyone else — not to the CKCS Club, the Kennel Club, the donors to Rupert’s Fund, the Fund organisers, or to any other individual or group. If owners want to discuss their results, that is their personal choice. Some have shared results to encourage others to scan!

Who are the researchers? They include:

◦The neurologist doing the actual scan

◦Dr Clare Rusbridge, who interprets each scan for consistency across the project

◦The Canadian genome group, who will use the results for the genome work

◦Dr Sarah Blott and/or Tom Lewis, as the scan is shared with their Estimated Breeding Values (EBV) project

And no one else!

For further information, people can speak with Penny Knowler or Clare Rusbridge directly.

DO you have a cavalier that has already been MRI scanned?

Many pet owners and breeders around the world have scanned their cavaliers either for breeding information or for clinical reasons. These are ALL valuable to research, if the dog has a registration number to a national kennel club organisation, and a pedigree (however a dog does not need to have a printed pedigree — one can be determined from the registration number of the dog, by researchers). If you already have a scan for a dog that was scanned at age 6+, this may be very useful to the genome work, whatever the result. Please contact the researchers for further information.

An MRI scan of ANY registered cavalier, of ANY age in ANY country, is of great value to Dr Sarah Blott’s EBV research. Because of a shortage of such information — often due to an incorrect assumption that all scanning centres forward on MRI results to the researchers, or lack of awareness about the EBV project — researchers have not yet been able to launch the EBV programme for breeders. Thus any information from any cavaliers worldwide is now desired (not just from UK cavaliers). To find out more about submitting a scan (and when possible, cardiologist results and/or eye exam results), or to submit health information, contact:

Dr Sarah Blott
CKCS Health Breeding Programme
Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU
This can also be done by email: sarah.blott@aht.org.uk

During the creation of this event I was able to have extensive email conversations back and forth with Penny Knowler and in doing so they have updated their call for Cavaliers to include the following Cavaliers:

Active Stud Dogs over the age of 5
Bitches over 6 years old who have been scanned clear at 3 years or older
Asymptomatic Bitches 8 years or older with unknown MRI status but with SM clear close relatives

This change was done in the hopes of finding the Cavaliers necessary for a larger research database. You can apply no matter where in the world you are located and if chosen they will work with you in locating a proper MRI facility that meets their needs and can work within their guidelines. Your Cavalier will never be poked, prodded, used for surgery or given any medication as a result of being chosen. Your dog will be have Anesthesia administered before the MRI and a possible sample of their blood will be taken in order to send to the Canadian Genome Research Team.

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Comments

  1. Anonymous says:
  2. Anonymous says:

    Ste-Justine Hospital Research Center and The Center for the Study of Brain Diseases
    C/O Dr Zoha Kibar,
    3175 Cote-Ste-Catherine,Room A711,
    Montreal, QC Canada
    H3T 1C5

    Genome Project

  3. Anonymous says:

    Payable to:
    The Royal Veterinary College

    C/O Dr Imelda McGonnell
    Room T16, Hobday Building
    Dept Veterinary Basic Sciences RVC,
    Royal College Street
    London
    NW10TU

  4. Anonymous says:

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